TranspoScope: interactive visualization of retrotransposon insertions
نویسندگان
چکیده
منابع مشابه
euL1db: the European database of L1HS retrotransposon insertions in humans
Retrotransposons account for almost half of our genome. They are mobile genetics elements-also known as jumping genes--but only the L1HS subfamily of Long Interspersed Nuclear Elements (LINEs) has retained the ability to jump autonomously in modern humans. Their mobilization in germline--but also some somatic tissues--contributes to human genetic diversity and to diseases, such as cancer. Here,...
متن کاملAnalysis of yeast retrotransposon Ty insertions at the CAN1 locus.
The target site distribution for 55 independent Ty insertions that inactivate the function of the Saccharomyces cerevisiae CAN1 gene is reported. Under some selection conditions Ty elements inserted preferentially into the promoter and exhibited an orientation bias. In contrast, under other conditions no insertions were detected in the promoter region and transposition appeared to occur randoml...
متن کاملSplicing of retrotransposon insertions from transcripts of the Drosophila melanogaster vermilion gene in a revertant.
A mutation of the Drosophila melanogaster vermilion (v) gene known as v1 is caused by the insertion of a 412 retrotransposon into the 5' untranslated region of the first exon. Mutants carrying this insertion accumulate a low level of mRNA from which most of the transposon sequences have been eliminated by splicing at cryptic sites within transposon sequences. Here, we demonstrate that a reverta...
متن کاملInsertional polymorphism and antiquity of PDR1 retrotransposon insertions in pisum species.
Sequences flanking 73 insertions of the retrotransposon PDR1 have been characterized, together with an additional 270 flanking regions from one side alone, from a diverse collection of Pisum germ plasm. Most of the identified flanking sequences are repetitious DNAs but more than expected (7%) lie within nuclear gene protein-coding regions. The approximate age of 52 of the PDR1 insertions has be...
متن کاملInteractive Simulation of Flexible Needle Insertions Based on Constraint Models
This paper presents a new modeling method for the insertion of needles and more generally thin and flexible medical devices into soft tissues. Several medical procedures rely on the insertion of slender medical devices such as biopsy, brachytherapy, deep-brain stimulation. In this paper, the interactions between soft tissues and flexible instruments are reproduced using a set of dedicated compl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioinformatics
سال: 2020
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btaa244